ASCO/ASTRO/SNO Guideline on Treatment of Brain Metastases
Guideline published: December 2021
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This multisociety guideline addresses the role of surgery, radiation therapy, and systemic therapy in the treatment of patients with brain metastases. For each of these therapies, a set of clinical questions was considered (summarized below). ASTRO is also publishing a complementary guideline focused only on radiation therapy for brain metastases, which expands on these radiation questions.
- Surgery: Benefits and harms of surgery and of laser interstitial thermal therapy.
- Systemic therapy: Which systemic therapy options, alone or in combination, have demonstrated clinical benefits.
- Radiation therapy: Benefits and harms of whole brain radiation therapy (WBRT); Approaches to mitigate the harms of WBRT; Benefits and harms of: stereotactic radiosurgery (SRS); SRS compared to WBRT; and use of radiation sensitizers?
Developed in collaboration with and endorsed by:
- American Society of Clinical Oncology
- American Society for Radiation Oncology
- Society for Neuro-Oncology
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