ASTRO 2025 has been uniquely designed to ensure that attendees from around the globe continue to access timely scientific and educational content. The theme for the 2025 ASTRO Annual Meeting is “Rediscovering Radiation Medicine and Exploring New Indications.” This five-day live meeting is designed to improve professional practice by increasing attendees' level of knowledge as required to improve competency and performance in the field of radiation oncology and radiation applications.