Research Primer References

The following publications were used as references to generate the content of the research primers:

• Drake, CG and Pardoll D et al., Mechanisms of Immune Evasion by Tumors. Advances in Immunology. 2006. 90, 51-81
• Janeway, CA, Travers, P, and Shlomchik., MJ., Immunobiology, 5th edition. The Immune System in Health and Disease. New York: Garland Science; 2001
• Iwasaki A1, Medzhitov R1. Control of Adaptive immunity by the innate immune syste. Nat Immunol. 2015 Apr; 16(4):343-53
• Pauken KE, Wherry EJ. Overcoming T cell exhaustion in infection and Cancer. Trends Immunol. 2015 Apr;36(4):265-76
• Schreiber RD1, Old LJ, Smyth MJ. Cancer Immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011 Mar 25; 331(6024):1565-70
• Smyth M, Ngiow S, Ribas A, Teng M. Combination cancer immunotherapies tailored to the tumor microenviroment. Nature Reviews Clinical Oncology. 2015. vol: 13 (3) pp: 143-158
• Topalian S, Drake C and Pardoll. Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy. Cancer Cel.l. 2015 vol: 27 (4) pp: 450-461
• Tumeh P and Ribas, A. PD-1 blockade induces response by inhibiting adaptive immune resistance. Nature 2014 vol: 515 (7528) pp: 568-71
• Wan YY1, Flavell RA. The roles for cytokines in the generation and maintenance of regulatory T cells. Immunol Rev. 2006 Aug; 212:114-30
• Bernier J, Hall EJ, Giaccia A. Radiation oncology: a century of achievements. Nat Reviews Cancer 2004; 4:737-47
• Abeloff MD, et al. Clinical Oncology. 3^rd ed. Philadelphia: Churchill Livingstone, 2004
• Demaria S, Golden EB, Formenti SC. Role of local radiation therapy in cancer immunotherapy. Jama Oncol 2015; 1(9):1325-32
• Bernstein MB et al. Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach? Nat Rev Clin Oncol 2016; 13(8): 516-24
• Postow MA et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 2012; 366(10):925-31
• Hiniker SM et al. A systemic complete response of metastatic melanoma to local radiation and immunotherapy. Transl Oncol 2012; 5(6):404-407
• Golden EB et al. An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res 2013; 1(6):365-72
• Twyman-Saint Victor C et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 2015; 520(7547):373-77